S100A12 triggers NETosis to aggravate myocardial infarction injury via the Annexin A5-calcium axis

S100A12 triggers NETosis to aggravate myocardial infarction injury via the Annexin A5-calcium axis

Abstract Neutrophil extracellular traps (NETs) play a critical role in acute myocardial infarction (AMI) and the externalization of S100 family members. Here, we show the effects of S100A12 on NETs formation and myocardial injury following AMI. S100A12 expression increases rapidly in neutrophils and...

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Main Authors: Xi Zhang, Haixu Song, Dan Liu, Yi Cai, Ziqi Liu, Xiaolin Zhang, Xiaojie Zhao, Yan Zhang, Quanmin Jing, Chenghui Yan, Yaling Han
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56978-5
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https://doi.org/10.1038/s41467-025-56978-5

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