Increased MLH1, MGMT, and p16INK4a methylation levels in colon mucosa potentially useful as early risk marker of colon cancer

Increased MLH1, MGMT, and p16INK4a methylation levels in colon mucosa potentially useful as early risk marker of colon cancer

The genes MutL Homolog 1 (MLH1), O6-methylguanine-DNA methyltransferase (MGMT), and cyclin-dependent kinase inhibitor p16INK4a are commonly downregulated by hypermethylation in colorectal cancer. Long interspersed nucleotide element 1 (LINE-1) can be used as marker for global hypomethylation. This s...

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Bibliographic Details
Main Authors: Yvonne Wettergren, Peter Rolny, Helena Lindegren, Elisabeth Odin, Victoria Rotter Sopasakis, Simon Keane, Katarina Ejeskär
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Molecular & Cellular Oncology
Subjects:
Colon cancer
normal mucosa
methylation; MLH1
MGMT
CDKN2a
LINE-1
Online Access:https://www.tandfonline.com/doi/10.1080/23723556.2025.2503069
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https://www.tandfonline.com/doi/10.1080/23723556.2025.2503069

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