PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype.

PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype.

Programmed cell death protein 1 (PD-1) is expressed on T cells upon T cell receptor (TCR) stimulation. PD-1 ligand 1 (PD-L1) is expressed in most tumor environments, and its binding to PD-1 on T cells drives them to apoptosis or into a regulatory phenotype. The fact that PD-L1 itself is also express...

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Main Authors: Giorgia Fanelli, Marco Romano, Estefania Nova-Lamperti, Mariana Werner Sunderland, Alessandra Nerviani, Cristiano Scottà, Michele Bombardieri, Sergio A Quezada, Steven H Sacks, Randolph J Noelle, Costantino Pitzalis, Robert I Lechler, Giovanna Lombardi, Pablo D Becker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-04-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001199&type=printable
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https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001199&type=printable

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