PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2

PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2

Abstract In search for broad-spectrum antivirals, we discover a small molecule inhibitor, RMC-113, that potently suppresses the replication of multiple RNA viruses including SARS-CoV-2 in human lung organoids. We demonstrate selective inhibition of the lipid kinases PIP4K2C and PIKfyve by RMC-113 an...

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Main Authors: Marwah Karim, Manjari Mishra, Chieh-Wen Lo, Sirle Saul, Halise Busra Cagirici, Manon Gourdelier, Luca Ghita, Amrita Ojha, Do Hoang Nhu Tran, Aditi Agrawal, Connor McGraw, Michael P. East, Karen Anbro Gammeltoft, Malaya Kumar Sahoo, Nancie A. Mooney, Gary L. Johnson, Soumita Das, Pieter Leyssen, Johan Neyts, Winston Chiu, Courtney A. Cohen, Jens Bukh, Judith Gottwein, John M. Dye, Norma Neff, Peter K. Jackson, Benjamin A. Pinsky, Tuomo Laitinen, Tatu Pantsar, Antti Poso, Fabio Zanini, Steven De Jonghe, Christopher R. M. Asquith, Shirit Einav
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61759-1
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https://doi.org/10.1038/s41467-025-61759-1

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