Valsartan/2-Aminopyridine Co-Amorphous System: Preparation, Characterization, and Supramolecular Structure Simulation by Density Functional Theory Calculation

Valsartan/2-Aminopyridine Co-Amorphous System: Preparation, Characterization, and Supramolecular Structure Simulation by Density Functional Theory Calculation

The objective of this work was to improve the solubility and discover a stable co-amorphous form of valsartan (VAL), a BCS class-II drug, by utilizing small molecule 2-Aminopyridine (2-AP) in varying molar ratios (2:1, 1:1, and 1:2), employing a solvent evaporation technique. Additionally, by way of...

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Bibliographic Details
Main Authors: Linjie Wang, Chunan Du, Yang Yang, Pengtu Zhang, Shiling Yuan
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Molecules
Subjects:
co-amorphous
valsartan
DFT
supermolecule
intermolecular connectivity
Online Access:https://www.mdpi.com/1420-3049/29/22/5467
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