African swine fever virus MGF505-4R facilitates cGAS degradation through TOLLIP-mediated selective autophagy and inhibits the formation of ISGF3 to evade innate immunity

African swine fever virus MGF505-4R facilitates cGAS degradation through TOLLIP-mediated selective autophagy and inhibits the formation of ISGF3 to evade innate immunity

Abstract African swine fever virus (ASFV) causes acute and highly lethal disease in pigs. To counteract host defense systems and facilitate virus infection, many ASFV-encoded proteins have regulatory effects on the innate immune response. In this study, we constructed an MGF505-4R-deleted ASFV strai...

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Bibliographic Details
Main Authors: Manman Yao, Pengfei Li, Xiangmin Li, Wentao Li, Ping Qian
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Veterinary Research
Subjects:
ASFV
MGF505-4R
degradation
autolysosome
cGAS-STING
immune evasion
Online Access:https://doi.org/10.1186/s13567-025-01569-x
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https://doi.org/10.1186/s13567-025-01569-x

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