Struct2SL: Synthetic lethality prediction based on AlphaFold2 structure information and Multilayer Perceptron

In cancer therapeutics, the elucidation of synthetic lethality principles introduces transformative concepts for devising novel treatment paradigms. Computational methods to predict synthetic lethal (SL) gene pairs have potential to markedly enhance the precision and efficacy of cancer interventions...

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Bibliographic Details
Main Authors: Yurui Huang, Ruzhe Yuan, Yaxuan Li, Zheming Xing, Junyi Li
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Computational and Structural Biotechnology Journal
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Online Access:http://www.sciencedirect.com/science/article/pii/S2001037025001345
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