Sulforaphane Restores Mitochondrial β-Oxidation and Reduces Renal Lipid Accumulation in a Model of Releasing Unilateral Ureteral Obstruction

Sulforaphane Restores Mitochondrial β-Oxidation and Reduces Renal Lipid Accumulation in a Model of Releasing Unilateral Ureteral Obstruction

Obstructive nephropathy (ON), characterized by urine flow disruption, can induce chronic kidney disease (CKD). Although the release of the obstruction is performed as the primary intervention, renal pathology often persists and progresses. Accordingly, the murine model of releasing unilateral ureter...

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Main Authors: Ana Karina Aranda-Rivera, Isabel Amador-Martínez, Omar Emiliano Aparicio-Trejo, Juan Carlos León-Contreras, Rogelio Hernández-Pando, Emma Saavedra, Fernando E. García-Arroyo, José Pedraza-Chaverri, Laura Gabriela Sánchez-Lozada, Edilia Tapia
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Antioxidants
Subjects:
obstructive nephropathy (ON)
sulforaphane (SFN)
mitochondrial biogenesis
β-oxidation
fatty acid metabolism
mitochondrial dynamics
Online Access:https://www.mdpi.com/2076-3921/14/3/288
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