Rapidly Manufactured CAR-T with Conserved Cell Stemness and Distinctive Cytokine-Secreting Profile Shows Improved Anti-Tumor Efficacy

Rapidly Manufactured CAR-T with Conserved Cell Stemness and Distinctive Cytokine-Secreting Profile Shows Improved Anti-Tumor Efficacy

<b>Background:</b> The emergence of chimeric antigen receptor T-cell (CAR-T) immunotherapy holds great promise in treating hematologic malignancies. While advancements in CAR design have enhanced therapeutic efficacy, the time-consuming manufacturing process has not been improved in the...

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Bibliographic Details
Main Authors: Shih-Ting Tsao, Mingyuan Gu, Qinghui Xiong, Yingzhi Deng, Tian Deng, Chengbing Fu, Zihao Zhao, Haoyu Zhang, Cuicui Liu, Xiong Zhong, Fang Xiang, Fei Huang, Haiying Wang
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Vaccines
Subjects:
chimeric antigen receptor T-cell
CD19
B-cell acute lymphoblastic leukemia
rapid manufacture
cytokine-secreting profile of CAR-T
stemness of CAR-T
Online Access:https://www.mdpi.com/2076-393X/12/12/1348
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