Systemic role of orexin A, substance P, bradykinin, and DABK in severe COVID-19 and 2.5-yr follow-ups: an observational study

Systemic role of orexin A, substance P, bradykinin, and DABK in severe COVID-19 and 2.5-yr follow-ups: an observational study

Background: Orexin A regulates sleep–wake cycles, arousal, and energy homeostasis, linking it to the renin–angiotensin system and substance P. Dysfunction in these pathways occurs in acute and long-term COVID-19, including post-COVID syndrome. Methods: This observational study analysed plasma orexin...

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Bibliographic Details
Main Authors: Ulrike Heinicke, Steven R. Talbot, Filippos Thanasis, Elisabeth H. Adam, Andreas von Knethen, Andrea U. Steinbicker, Sebastian Zinn, Kai Zacharowski, Armin N. Flinspach
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:BJA Open
Subjects:
acute respiratory distress syndrome
deep sedation
des-Arg9-bradykinin
intensive care unit
orexin A
post-acute COVID-19 syndrome
Online Access:http://www.sciencedirect.com/science/article/pii/S2772609625000395
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