Efficacy of cartilage-targeted IGF-1 in a mouse model of growth hormone insensitivity

Efficacy of cartilage-targeted IGF-1 in a mouse model of growth hormone insensitivity

Recombinant human IGF-1 is used to treat severe primary IGF-1 deficiency, but this treatment requires twice-daily injection, often does not fully correct the growth deficit, and has important off-target effects. We therefore sought to target IGF-1 to growth plate cartilage by generating fusion prote...

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Bibliographic Details
Main Authors: Krishma Tailor, Janine van Ree, Timothy Stowe, Brit Ventura, Connor Sisk, Joanna Courtis, Anna Camp, Fatima Elzamzami, Jan van Deursen, Robert O’Brien, Jeffrey Baron, Julian C. Lui
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Endocrinology
Subjects:
short stature
matrilin-3
GH-insensitivity syndrome
hypoglycemia
drug targeting
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1523931/full
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https://www.frontiersin.org/articles/10.3389/fendo.2024.1523931/full

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