Xanthocillin X Dimethyl Ether Exhibits Anti-Proliferative Effect on Triple-Negative Breast Cancer by Depletion of Mitochondrial Heme

Xanthocillin X Dimethyl Ether Exhibits Anti-Proliferative Effect on Triple-Negative Breast Cancer by Depletion of Mitochondrial Heme

Triple-negative breast cancer (TNBC) presents a significant therapeutic challenge due to the absence of specific targeted treatments. In this study, we explored the therapeutic potential of xanthocillin X dimethyl ether (XanDME), a naturally occurring isocyanide isolated from the marine fungus <i...

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Bibliographic Details
Main Authors: Jingjing Du, Xuening Zhang, Kaiqiang Guo, Wanjun Lin, Wenjian Lan, Zi Wang, Meina Shi, Zifeng Huang, Houjin Li, Wenzhe Ma
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Marine Drugs
Subjects:
xanthocillin X dimethyl ether
triple-negative breast cancer
heme
mitochondria
Online Access:https://www.mdpi.com/1660-3397/23/4/146
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