Intercellular adhesion molecule-1 protects against adipose tissue inflammation and insulin resistance but promotes liver disease activity in western-diet fed mice

Intercellular adhesion molecule-1 protects against adipose tissue inflammation and insulin resistance but promotes liver disease activity in western-diet fed mice

Abstract Metabolic dysfunction associated steatotic liver disease (MASLD) presents a growing global health problem. Disease progression is promoted not only by hepatic leukocyte accumulation but also by inflammatory signals from adipose tissue and an altered gut microbiome. To determine the contribu...

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Main Authors: Sreepradha Eswaran, Laura Gebert, Sarah Schraven, Nicole Treichel, Thomas Ritz, Sabine Hamm, Agnes Seeger, Fabian Kiessling, Thomas Clavel, Stephan Dreschers, Norbert Wagner, Angela Schippers
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
ICAM-1
Western diet
Metabolic syndrome
Steatohepatitis
Microbiome
MASLD
Online Access:https://doi.org/10.1038/s41598-025-11555-0
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https://doi.org/10.1038/s41598-025-11555-0

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