Proteoglycans Enhance the Therapeutic Effect of BMSC Transplantation on Osteoarthritis

Proteoglycans Enhance the Therapeutic Effect of BMSC Transplantation on Osteoarthritis

Background: The injection of bone mesenchymal stem cells (BMSCs) for osteoarthritis (OA) treatment fails to address the disrupted extracellular microenvironment, limiting the differentiation and paracrine functions of BMSCs and resulting in suboptimal therapeutic outcomes. Proteoglycans (PGs) promot...

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Bibliographic Details
Main Authors: Chunxiao Ran, Tianhao Liu, Yongming Bao, Weidan Wang, Dongling Xue, Guangxiao Yin, Xiuzhi Zhang, Dewei Zhao
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Bioengineering
Subjects:
proteoglycans
bone marrow mesenchymal stem cells
cartilage repair
paracrine
osteoarthritis
Online Access:https://www.mdpi.com/2306-5354/11/11/1167
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