Role of IgG4 Antibodies in Human Health and Disease

Role of IgG4 Antibodies in Human Health and Disease

Immunoglobulin G4 (IgG4), a unique subclass of IgG antibodies, plays diverse roles in human health and disease. Its distinct features, such as Fab-arm exchange and specific mutations, confer reduced effector functions compared to other IgG subclasses. In health, IgG4 responses contribute to immune t...

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Bibliographic Details
Main Authors: Li-li Shi, Peng Xiong, Minglin Yang, Ozge Ardicli, Stephan Raphael Schneider, Anders Boutrup Funch, Ayca Kiykim, Juan Lopez, Cezmi A. Akdis, Mübeccel Akdis
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Cells
Subjects:
IgG4
immune tolerance
allergen-specific immunotherapy (AIT)
autoimmune disease
allergic disease
chronic infection
Online Access:https://www.mdpi.com/2073-4409/14/9/639
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