Inflammatory factor CCL2 enhances the interaction between monocyte-macrophage cells and liver parenchymal cells to promote liver inflammation and fibrosis in biliary atresia

Inflammatory factor CCL2 enhances the interaction between monocyte-macrophage cells and liver parenchymal cells to promote liver inflammation and fibrosis in biliary atresia

Abstract Background Liver fibrosis in biliary atresia (BA) progresses rapidly and has distinct characteristics; however, current studies have not identified effective prevention or treatment strategies to address this issue. Methods BA liver tissues with different degrees of liver fibrosis (n = 4),...

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Main Authors: Xin Li, Shaowen Liu, Tengfei Li, Qianhui Yang, Yuqiang Chen, Yu Meng, Zhiru Wang, Yilin Zhao, Shujian Zhang, Liang Ge, Alimujiang Abudureyimu, Jianghua Zhan
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Pediatrics
Subjects:
Biliary atresia (BA)
Liver fibrosis
Inflammation
Single-cell RNA sequencing (scRNA-seq)
Spatial transcriptomics (ST)
Mendelian randomization (MR)
Online Access:https://doi.org/10.1186/s12887-025-05984-z
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https://doi.org/10.1186/s12887-025-05984-z

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