Hypoxia Induced Downregulation of Na+/H+ Exchanger-1 Activity Decreases Tumor Cell Proliferation

Hypoxia Induced Downregulation of Na+/H+ Exchanger-1 Activity Decreases Tumor Cell Proliferation

Objectives: Hypoxia and acidosis are the hallmarks of proliferative tumor microenvironment which can modulate the expression and function of Na+/H+ exchanger-1 (NHE1) via hypoxia inducible factor 1 (Hif). Here, we investigate the severity and time dependent effects of chronic hypoxia on NHE1 activit...

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Bibliographic Details
Main Authors: Gül Şimşek, Hilmi Burak Kandilci
Format: Article
Language:English
Published: Galenos Publishing House 2025-03-01
Series:Ankara Üniversitesi Tıp Fakültesi Mecmuas
Subjects:
cell culture techniques
hypoxia
sodium-hydrogen exchangers
neoplasms
Online Access:https://www.ankaratipfakultesimecmuasi.net/articles/hypoxia-induced-downregulation-of-nalesssupgreaterlesssupgreaterhlesssupgreaterlesssupgreater-exchanger-1-activity-decreases-tumor-cell-proliferation/doi/atfm.galenos.2025.98624
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https://www.ankaratipfakultesimecmuasi.net/articles/hypoxia-induced-downregulation-of-nalesssupgreaterlesssupgreaterhlesssupgreaterlesssupgreater-exchanger-1-activity-decreases-tumor-cell-proliferation/doi/atfm.galenos.2025.98624

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