MMP-9 Activation via ROS/NF-κB Signaling in Colorectal Cancer Progression: Molecular Insights and Prognostic–Therapeutic Perspectives

MMP-9 Activation via ROS/NF-κB Signaling in Colorectal Cancer Progression: Molecular Insights and Prognostic–Therapeutic Perspectives

Colorectal cancer (CRC) is characterized by complex interactions between inflammation, oxidative stress, and extracellular matrix remodeling. Recent studies have highlighted the significance of the reactive oxygen species (ROS)–nuclear factor kappa B (NF-κB)–matrix metalloproteinase-9 (MMP-9) axis i...

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Main Authors: Andrej Veljkovic, Goran Stanojevic, Branko Brankovic, Stefanos Roumeliotis, Konstantinos Leivaditis, Branka Djordjevic, Xiaobo Li, Aleksandra Klisic, Jovan Hadzi-Djokic, Gordana Kocic
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Current Issues in Molecular Biology
Subjects:
colorectal cancer
NF-κB
AOPP
MMP-9
Online Access:https://www.mdpi.com/1467-3045/47/7/557
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