A novel isoquinoline mitophagy inducer ameliorates paclitaxel-induced peripheral neuropathy in Drosophila and mouse models

A novel isoquinoline mitophagy inducer ameliorates paclitaxel-induced peripheral neuropathy in Drosophila and mouse models

Abstract Chemotherapy-induced peripheral neuropathy (CIPN) resulting from neurodegeneration due to chemotherapy is a challenging complication of widely administered anticancer drugs including paclitaxel. Although CIPN is common and limits the use of chemotherapies, no curative treatment for CIPN has...

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Bibliographic Details
Main Authors: Sangwoo Im, Se Myeong Choi, Young Yeon Kim, Dae Jin Jeong, Jee-Hyun Um, Kang-Min Lee, Eunhee Yoo, Jong Hyun Cho, Ji Hyun Lee, Jeanho Yun
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Peripheral neuropathy
Paclitaxel
Mitophagy
Neuronal degeneration
Online Access:https://doi.org/10.1038/s41598-025-04178-y
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https://doi.org/10.1038/s41598-025-04178-y

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