Metformin for knee osteoarthritis with obesity: study protocol for a randomised, double-blind, placebo-controlled trial

Introduction Over half of the populations with knee osteoarthritis (OA) have obesity. These individuals have many other shared metabolic risk factors. Metformin is a safe, inexpensive, well-tolerated drug that has pleiotropic effects, including structural protection, anti-inflammatory and analgesic...

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Bibliographic Details
Main Authors: Yuanyuan Wang, Flavia M Cicuttini, Stephane Heritier, Mahnuma Mahfuz Estee, Anita E Wluka, Yuan Z Lim, Donna M. Urquhart
Format: Article
Language:English
Published: BMJ Publishing Group 2023-12-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/13/12/e079489.full
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