Inhibition of adaptive immune responses leads to a fatal clinical outcome in SIV-infected pigtailed macaques but not vervet African green monkeys.

Inhibition of adaptive immune responses leads to a fatal clinical outcome in SIV-infected pigtailed macaques but not vervet African green monkeys.

African green monkeys (AGM) and other natural hosts for simian immunodeficiency virus (SIV) do not develop an AIDS-like disease following SIV infection. To evaluate differences in the role of SIV-specific adaptive immune responses between natural and nonnatural hosts, we used SIV(agmVer90) to infect...

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Main Authors: Jörn E Schmitz, Roland C Zahn, Charles R Brown, Melisa D Rett, Ming Li, Haili Tang, Sarah Pryputniewicz, Russell A Byrum, Amitinder Kaur, David C Montefiori, Jonathan S Allan, Simoy Goldstein, Vanessa M Hirsch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000691&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000691&type=printable

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