MYO1B promotes radioresistance in head and neck squamous cell carcinoma by regulating tumor stemness and DNA damage repair via the PI3K/AKT pathway

MYO1B promotes radioresistance in head and neck squamous cell carcinoma by regulating tumor stemness and DNA damage repair via the PI3K/AKT pathway

Abstract Head and Neck Squamous Cell Carcinoma is a prevalent malignancy characterized by high recurrence rates. While surgery remains the primary treatment, postoperative radiotherapy is essential for preventing tumor recurrence. However, the mechanisms driving radiotherapy resistance in HNSC remai...

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Bibliographic Details
Main Authors: Yanan Li, Jiahao Liu, Zhen Wang, Yilei Zhang, Baiying Liu, Ling Chu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cancer Cell International
Subjects:
MYO1B
Radioresistance
Head and neck squamous cell carcinoma
Cell stemness
DNA damage
PI3K/AKT pathway
Online Access:https://doi.org/10.1186/s12935-025-03863-2
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https://doi.org/10.1186/s12935-025-03863-2

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