E3 ligase HERC5-catalyzed UGDH isgylation promotes SNAI1-mediated tumor metastasis and cisplatin resistance in oral squamous cell carcinoma

E3 ligase HERC5-catalyzed UGDH isgylation promotes SNAI1-mediated tumor metastasis and cisplatin resistance in oral squamous cell carcinoma

Abstract Background Oral squamous cell carcinoma (OSCC) is one of the leading causes of cancer-related mortality worldwide due to its high aggressive potential and drug resistance. Previous studies have revealed an important function of HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 5 (H...

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Bibliographic Details
Main Authors: Xu Zhang, Fayu Liu, Qigen Fang, Changfu Sun, Jie Fan
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Biology Direct
Subjects:
HERC5
Oral squamous cell carcinoma
Metastasis
Cisplatin sensitivity
ISGylation
UGDH
Online Access:https://doi.org/10.1186/s13062-025-00622-1
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https://doi.org/10.1186/s13062-025-00622-1

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