Differential landscape of immune evasion in oncogenic RAS-driven primary and metastatic colorectal cancers

Differential landscape of immune evasion in oncogenic RAS-driven primary and metastatic colorectal cancers

Oncogenic drivers such as KRAS extensively modulate the tumor inflammatory microenvironment (TIME) of colorectal cancer (CRC). The influence of KRAS on modulating immune cell composition remains unclear. The objective of this study was to identify signatures of infiltrative immune cells and distinct...

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Main Authors: Emil Lou, Joanne Xiu, Yasmine Baca, Anwaar Saeed, Ajay Prakash, Sepideh Gholami, Subbaya Subramanian, Timothy K. Starr, Elisa Fontana, Ritu Pandey, Heinz-Josef Lenz, Anthony F. Shields, Chadi Nabhan, Matthew Oberley, Andreas Seeber, Wafik El-Deiry
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
colorectal cancer
KRAS
RAS
immunoevasion
immune infiltration
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329924000286
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