Patient-derived colorectal microtumors predict response to anti-PD-1 therapy

Patient-derived colorectal microtumors predict response to anti-PD-1 therapy

Immune checkpoint inhibitors have made remarkable impacts in treating various cancers, including colorectal cancer (CRC). However, CRC still remains a leading cause of cancer-related deaths. While microsatellite instability (MSI) CRC has shown positive responses to anti-PD-1 therapy, this subgroup r...

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Main Authors: Duy T. Nguyen, Matthew A. Schaller, Krista P. Terracina, Xia Xu, Diego I. Pedro, Alfonso Pepe, Juan M. Urueña, Zadia Dupee, Nickolas Diodati, Ryan A. Smolchek, Jack E. Famiglietti, Nhi Tran Yen Nguyen, Gerik W. Tushoski-Alemán, Kuoyuan Cheng, Lan Chen, Doug Linn, Vania Vidimar, Aquila Fatima, Soon Woo Kwon, Dongyu Sun, Hongmin Chen, Haiyan Xu, Brian Long, Lily Y. Moy, Bonnie J. Howell, George H. Addona, W. Gregory Sawyer
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
colorectal cancer
CRC
microsatellite instability
immune checkpoint inhibitor
immunotherapy
anti-PD-1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1640500/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1640500/full

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