Critical role of ROCK1 in AD pathogenesis via controlling lysosomal biogenesis and acidification

Critical role of ROCK1 in AD pathogenesis via controlling lysosomal biogenesis and acidification

Abstract Background Lysosomal homeostasis and functions are essential for the survival of neural cells. Impaired lysosomal biogenesis and acidification in Alzheimer’s disease (AD) pathogenesis leads to proteolytic dysfunction and neurodegeneration. However, the key regulatory factors and mechanisms...

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Main Authors: Chenghuan Song, Wanying Huang, Pingao Zhang, Jiyun Shi, Ting Yu, Jing Wang, Yongbo Hu, Lanxue Zhao, Rui Zhang, Gang Wang, Yongfang Zhang, Hongzhuan Chen, Hao Wang
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Translational Neurodegeneration
Subjects:
ROCK1
Lysosomal biogenesis
Lysosomal acidification
TFEB
Alzheimer’s disease
Online Access:https://doi.org/10.1186/s40035-024-00442-9
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https://doi.org/10.1186/s40035-024-00442-9

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