Repeated lidocaine exposure induces synaptic and cognitive impairment in aged mice by activating microglia and neurotoxic A1 astrocytes

Repeated lidocaine exposure induces synaptic and cognitive impairment in aged mice by activating microglia and neurotoxic A1 astrocytes

Summary: In the perioperative setting, the administration of intravenous lidocaine is widespread. This study investigates the effects of varying frequencies of intravenous lidocaine on cognitive function in mice of differing ages. Young adult and aged mice received systemic lidocaine either once or...

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Bibliographic Details
Main Authors: Xiaohui Chen, Haiyang Wan, Yongxin Huang, Andi Chen, Xuyang Wu, Yanhua Guo, Jianjie Wei, Pinzhong Chen, Jiangdan Jiang, Xiaochun Zheng
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:iScience
Subjects:
Pharmacology
Neuroscience
Immunology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225003013
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http://www.sciencedirect.com/science/article/pii/S2589004225003013

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