Host-microbiome relationship in depression: can human induced pluripotent stem cells play a role in unravelling mechanisms?

Abstract Depression is highly prevalent, with many patients not responding to existing treatments. The gut microbiota plays a key role in its pathophysiology, offering new therapeutic avenues. Human-based research is essential to uncover mechanisms and validate new targets. Given CNS inaccessibility...

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Bibliographic Details
Main Authors: Cristina Rosell-Cardona, John F. Cryan, Gerard Clarke, Sarah Kittel-Schneider
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Biofilms and Microbiomes
Online Access:https://doi.org/10.1038/s41522-025-00749-z
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