Mossy Fiber Sprouting in Temporal Lobe Epilepsy: The Impact of Netrin-1, DCC, and Gene Expression Changes

Mossy Fiber Sprouting in Temporal Lobe Epilepsy: The Impact of Netrin-1, DCC, and Gene Expression Changes

Background: Temporal lobe epilepsy (TLE) is the most common form of drug-resistant epilepsy, often associated with hippocampal sclerosis (HS), which involves selective neuronal loss in the Cornu Ammonis subregion 1 CA1 and CA4 regions of the hippocampus. Granule cells show migration and mossy fiber...

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Bibliographic Details
Main Authors: Melis Onay, Patrick N. Harter, Katherina Weber, Albrecht Piiper, Marcus Czabanka, Karl H. Plate, Thomas M. Freiman, Florian Gessler, Barbara Puhahn-Schmeiser
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Biomedicines
Subjects:
temporal lobe epilepsy
hippocampal sclerosis
microglia
M1 phenotype
M2 phenotype
Netrin-1
Online Access:https://www.mdpi.com/2227-9059/12/12/2869
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