Multi-omics analysis uncovers predictive biomarkers for the efficacy and outcomes of chemoimmunotherapy in advanced unresectable biliary tract cancers

Multi-omics analysis uncovers predictive biomarkers for the efficacy and outcomes of chemoimmunotherapy in advanced unresectable biliary tract cancers

Abstract Background The limited response rates of immune checkpoint inhibitors in biliary tract cancers (BTC) highlight the need for effective biomarkers to optimize patient selection. Methods Baseline tumor tissues from 125 patients with advanced BTC treated with first-line chemoimmunotherapy (chem...

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Main Authors: Jiaojiao Ni, Chaoqun Li, Xiaoqing Xu, Qi Xu, Qian Yin, Hanlin Chen, Shurui Zhou, Jingjing Li, Qinhong Zheng, Yanru Xie, Hongjun Hua, Jianying Jin, Tieming Xie, Haiping Zhao, Feng Yan, Junjun Shen, Yihui Huang, Wangye Zheng, Junrong Yan, Xiaoying Wu, Song Wang, Qiuxiang Ou, Yang Shao, Wei Wu, Wei Zhuo, Jieer Ying
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Medicine
Subjects:
Immune checkpoint inhibitors
Biliary tract cancer
Next-generation sequencing
CXCL9
Online Access:https://doi.org/10.1186/s12916-025-04263-z
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https://doi.org/10.1186/s12916-025-04263-z

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