Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations

Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations

Abstract Heterozygous inactivating mutations in ribosomal protein genes (RPGs) are associated with hematopoietic and developmental abnormalities, activation of p53, and altered risk of cancer in humans and model organisms. Here we performed a large‐scale analysis of cancer genome data to examine the...

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Bibliographic Details
Main Authors: Ram Ajore, David Raiser, Marie McConkey, Magnus Jöud, Bernd Boidol, Brenton Mar, Gordon Saksena, David M Weinstock, Scott Armstrong, Steven R Ellis, Benjamin L Ebert, Björn Nilsson
Format: Article
Language:English
Published: Springer Nature 2017-03-01
Series:EMBO Molecular Medicine
Subjects:
cancer
ribosomal gene haploinsufficiency
ribosome function
Online Access:https://doi.org/10.15252/emmm.201606660
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https://doi.org/10.15252/emmm.201606660

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