Salsalate improves the anti-tumor efficacy of lenvatinib in MASH-driven hepatocellular carcinoma

Salsalate improves the anti-tumor efficacy of lenvatinib in MASH-driven hepatocellular carcinoma

Background & Aims: Metabolic dysfunction-associated steatohepatitis (MASH) is a growing cause of hepatocellular carcinoma (HCC) worldwide. The complex microenvironment of these tumors, characterized by metabolic dysfunction, hypoxia, steatosis, and fibrosis, limits the effectiveness of stand...

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Main Authors: Evangelia E. Tsakiridis, Elham Ahmadi, Jaya Gautam, Yi Ran Hannah She, Russta Fayyazi, James S.V. Lally, Simon Wang, Fiorella Di Pastena, Celina M. Valvano, Daniel Del Rosso, Olga-Demetra Biziotis, Brandon Meyers, Paola Muti, Theodoros Tsakiridis, Gregory R. Steinberg
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:JHEP Reports
Subjects:
Lipogenesis
Salicylic acid
Metabolic dysfunction-associated steatohepatitis
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555925000308
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