A base editing platform for the correction of cancer driver mutations unmasks conserved p53 transcription programs
Abstract Background Understanding the role of cancer hotspot mutations is essential for unraveling mechanisms of tumorigenesis and identifying therapeutic vulnerabilities. Correcting cancer mutations with base editing is a novel, yet promising approach for investigating the biology of driver mutatio...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
|
| Series: | Genome Biology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13059-025-03667-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|