Pharmacogenetics polygenic response score predicts outcomes in aspirin-treated stroke patients

Pharmacogenetics polygenic response score predicts outcomes in aspirin-treated stroke patients

BackgroundAspirin is a cornerstone medication for acute ischemic stroke (AIS), but its efficacy varies significantly among individuals. This study aimed to develop a pharmacogenetic polygenic response score (PgxRS) to predict the incidence of adverse outcomes in aspirin-treated AIS patients.MethodsW...

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Main Authors: Rui-Nan Ma, Dong Zhang, Zhi-Zhang Li, Ying Ding, Xiao-Guang Zhang, Jie Xue, Dan-Zhuoma Ci, Yue-Ying Bai, Liang Hu, Dai-Zhan Zhou, Yun-Hua Yue
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
aspirin
acute ischemic stroke
single nucleotide variant
pharmacogenetics
prognosis
personalized medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1519383/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1519383/full

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