CD73 promotes the immunoregulatory functions of hepatic Tregs through enzymatic and nonenzymatic pathways in MASLD development

CD73 promotes the immunoregulatory functions of hepatic Tregs through enzymatic and nonenzymatic pathways in MASLD development

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading chronic liver disease characterized by chronic inflammation. Regulatory T cells (Tregs) highly express CD73 and play a critical role in modulating the immune response. However, the roles and mechanisms by which CD73 modula...

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Main Authors: Hua Jin, Xinjie Zhong, Chunpan Zhang, Yongle Wu, Jie Sun, Xiyu Wang, Zeyu Wang, Jingjing Zhu, Yuan Jiang, Xiaonan Du, Zihan Zhang, Dong Zhang, Guangyong Sun
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Metabolism
Subjects:
CD73
Regulatory T cells
Metabolic dysfunction-associated steatotic liver disease
Adenosine
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Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000389
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