Piezo1 induces mitochondrial autophagy dysfunction leading to cartilage injury in knee osteoarthritis

Piezo1 induces mitochondrial autophagy dysfunction leading to cartilage injury in knee osteoarthritis

Abstract Background External mechanical stress plays a pivotal role in the pathogenesis of knee osteoarthritis. Piezo1 can sense mechanical stress changes on the surface of various cell types and convert them into bioelectrical signals to regulate cellular functions. Therefore, our study aimed to in...

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Bibliographic Details
Main Authors: Likai Yu, Zishan Su, Di Tian, Shangqi Liu, Li Zhang, Zeen Wang, Shaobo Guo, Wenhui Zhu, Peimin Wang, Nongshan Zhang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Molecular Medicine
Subjects:
Piezo1
Cartilage
Mitochondria
Autophagy
Knee osteoarthritis
Online Access:https://doi.org/10.1186/s10020-025-01335-x
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https://doi.org/10.1186/s10020-025-01335-x

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