Dorsal hyperintensity and iron deposition patterns in the substantia nigra of Parkinson’s disease, idiopathic REM sleep behavior disorder, and Parkinson-plus syndromes at 7T MRI: a prospective diagnostic study

Dorsal hyperintensity and iron deposition patterns in the substantia nigra of Parkinson’s disease, idiopathic REM sleep behavior disorder, and Parkinson-plus syndromes at 7T MRI: a prospective diagnostic study

Abstract Background Dorsal nigral hyperintensity (DNH) abnormality associated with excessive iron deposition in the substantia nigra, is recognized as an imaging characteristic of Parkinson’s disease (PD) and can be effectively visualized using 7T MRI. This study was aimed to develop and validate th...

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Main Authors: Dongning Su, Zhijin Zhang, Zhe Zhang, Rui Yan, Wanlin Zhu, Ning Wei, Yue Suo, Xinyao Liu, Ying Jiang, Lingyan Ma, Huiqing Zhao, Zhan Wang, Xuemei Wang, Huizi Ma, Xin Liu, Chaodong Wang, Zhirong Wan, Fangfei Li, Yuan Li, Joyce S. T. Lam, Junhong Zhou, Ning Zhang, Tao Wu, Jing Jing, Tao Feng
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Translational Neurodegeneration
Subjects:
7T MRI
Substantia nigra
Dorsal nigral hyperintensity
Iron deposition
Parkinson’s disease
Idiopathic rapid eye movement sleep behavior disorder
Online Access:https://doi.org/10.1186/s40035-025-00495-4
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https://doi.org/10.1186/s40035-025-00495-4

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