Genotype, Ethnicity, and Drug–Drug Interaction Modeling as Means of Verifying Transporter Biomarker PBPK Model: The Coproporphyrin‐I Story
ABSTRACT Coproporphyrin‐I (CP‐I) is a selective endogenous biomarker of organic anion‐transporting polypeptide (OATP)1B. Multiple CP‐I PBPK models with differing input parameters have been reported so far. This study proposed a harmonized CP‐I PBPK model and evaluated its ability to predict the effe...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-05-01
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| Series: | CPT: Pharmacometrics & Systems Pharmacology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/psp4.70008 |
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