IQGAP3 activates Hedgehog signaling to confer stemness and metastasis via up-regulating GLI1 in lung cancer

IQGAP3 activates Hedgehog signaling to confer stemness and metastasis via up-regulating GLI1 in lung cancer

Abstract Lung cancer ranks as the most prevalent malignant neoplasm worldwide, contributing significantly to cancer-related mortality. Stemness is a well-recognized factor underlying radiotherapy resistance, recurrence and metastasis in non-small-cell lung cancer (NSCLC) patients. Our prior investig...

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Bibliographic Details
Main Authors: Chang Li, Limei Liang, Jinyan Liang, Chen Tian, Juanjuan Wang, Yuting Liu, Xiaohua Hong, Feifei Gu, Kai Zhang, Yue Hu, Li Liu, Yulan Zeng
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
IQGAP3
GLI1
Hedgehog pathway
Stemness
Lung cancer
Online Access:https://doi.org/10.1038/s41598-024-82793-x
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https://doi.org/10.1038/s41598-024-82793-x

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