Multimodal and longitudinal characterization of distinct tau and atrophy clusters in Alzheimer’s disease spectrum

Multimodal and longitudinal characterization of distinct tau and atrophy clusters in Alzheimer’s disease spectrum

Abstract Neuropathological and neuroimaging studies have identified several (endo-)phenotypes of Alzheimer’s disease (AD), suggesting a substantial heterogeneity in cerebral atrophy and tau spreading patterns. We included in our study a total of 320 participants, including healthy controls (N = 154)...

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Bibliographic Details
Main Authors: Boris-Stephan Rauchmann, Ersin Ersözlü, Dorothea Luedecke, Nicolai Franzmeier, Robert Perneczky
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Similarity-based Louvain clustering
Cognitive decline and dementia
Precision medicine
Phenotypical heterogeneity
Online Access:https://doi.org/10.1038/s41598-025-98338-9
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https://doi.org/10.1038/s41598-025-98338-9

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