5′-Guanidino Xylofuranosyl Nucleosides as Novel Types of 5′-Functionalized Nucleosides with Biological Potential

5′-Guanidino Xylofuranosyl Nucleosides as Novel Types of 5′-Functionalized Nucleosides with Biological Potential

<b>Background/Objectives:</b> While various nucleoside and nucleotide analogs have been approved as anticancer and antiviral drugs, their limitations, including low bioavailability and chemotherapeutic resistance, encourage the development of novel structures. In this context, and motiva...

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Bibliographic Details
Main Authors: Jennifer Szilagyi, Tânia Moreira, Rafael Santana Nunes, Joana Silva, Celso Alves, Alice Martins, Rebeca Alvariño, Niels V. Heise, René Csuk, Nuno M. Xavier
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceuticals
Subjects:
nucleos(t)ide analogs
anticancer agents
cholinesterase inhibitors
neuroprotective compounds
guanidine moiety
N-glycosylatiom
Online Access:https://www.mdpi.com/1424-8247/18/5/734
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