PIN1-SUMO2/3 motif suppresses excessive RNF168 chromatin accumulation and ubiquitin signaling to promote IR resistance

PIN1-SUMO2/3 motif suppresses excessive RNF168 chromatin accumulation and ubiquitin signaling to promote IR resistance

Abstract RNF168 is an E3 ubiquitin ligase critical to the mammalian DNA double-strand break repair response. The protein is recruited to and amplifies ubiquitin signals at damaged chromatin and, if not properly regulated, can drive an uncontrolled ubiquitin cascade potentially harmful to repair outc...

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Main Authors: Anoop S. Chauhan, Matthew J. W. Mackintosh, Joseph Cassar, Alexander J. Lanz, Mohammed Jamshad, Hannah L. Mackay, Alexander J. Garvin, Alexandra K. Walker, Satpal S. Jhujh, Teresa Carlomagno, Aneika C. Leney, Grant S. Stewart, Joanna R. Morris
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56974-9
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https://doi.org/10.1038/s41467-025-56974-9

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