PGC1α regulates the mitochondrial metabolism response to cyclic stretch, which inhibits neointimal hyperplasia

PGC1α regulates the mitochondrial metabolism response to cyclic stretch, which inhibits neointimal hyperplasia

Abstract Neointimal hyperplasia occurs in the context of vascular injury, such as stent intervention or balloon angioplasty. However, the role of mechanical forces in this process remains to be studied. In this study, a rat carotid artery intimal injury model was established. RNA-sequencing and tran...

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Main Authors: Minwen Zou, Kaichuang Ye, Jing Yan, Shoumin Zhang, Han Bao, Zhiyin Li, Yuting Tao, Xing Zhang, Wenhao Tian, Yingxin Qi, Yunlong Huo, Yue Han
Format: Article
Language:English
Published: Springer 2025-08-01
Series:Cellular and Molecular Life Sciences
Subjects:
Vascular injury
Vascular smooth muscle cells
Cyclic stretch
Mitochondrial energy metabolism
PGC1α
Mechanotransduction
Online Access:https://doi.org/10.1007/s00018-025-05790-x
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https://doi.org/10.1007/s00018-025-05790-x

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