The E3 ubiquitin ligase MARCH2 controls TNF-α mediated inflammation by autoubiquitination

The E3 ubiquitin ligase MARCH2 controls TNF-α mediated inflammation by autoubiquitination

Abstract Background Regulation of the nuclear factor-kappa B (NF-kB) signaling pathway is a major host homeostatic mechanism for controlling hyper-inflammation or chronic inflammation. Despite extensive research, the regulatory factors of NF-kB signaling required to preserve homeostasis and control...

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Main Authors: Kiramage Chathuranga, Pramodya Rathnapala, Asela Weerawardhana, Tae-Hwan Kim, Yebin Seong, W. A. Gayan Chathuranga, Ashan Subasinghe, D. K. Haluwana, Nuwan Gamage, Youn Jung Choi, Jae U. Jung, Jong-Soo Lee
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cell Communication and Signaling
Subjects:
Autoubiquitination
Dimerization
IBD
MARCH2
MARCH8
Online Access:https://doi.org/10.1186/s12964-025-02260-6
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https://doi.org/10.1186/s12964-025-02260-6

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