The Raine syndrome protein FAM20C is a Golgi kinase that phosphorylates bio-mineralization proteins.

Raine syndrome is caused by mutations in FAM20C, which had been reported to encode a secreted component of bone and teeth. We found that FAM20C encodes a Golgi-localized protein kinase, distantly related to the Golgi-localized kinase Four-jointed. Drosophila also encode a Golgi-localized protein kin...

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Bibliographic Details
Main Authors: Hiroyuki O Ishikawa, Aiguo Xu, Eri Ogura, Gerard Manning, Kenneth D Irvine
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0042988&type=printable
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