Imaging NRF2 activation in non-small cell lung cancer with positron emission tomography

Imaging NRF2 activation in non-small cell lung cancer with positron emission tomography

Abstract Mutations in the NRF2-KEAP1 pathway are common in non-small cell lung cancer (NSCLC) and confer broad-spectrum therapeutic resistance, leading to poor outcomes. Currently, there is no means to non-invasively identify NRF2 activation in living subjects. Here, we show that positron emission t...

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Main Authors: Hannah E. Greenwood, Abigail R. Barber, Richard S. Edwards, Will E. Tyrrell, Madeleine E. George, Sofia N. dos Santos, Friedrich Baark, Muhammet Tanc, Eman Khalil, Aimee Falzone, Nathan P. Ward, Janine M. DeBlasi, Laura Torrente, Pritin N. Soni, David R. Pearce, George Firth, Lydia M. Smith, Oskar Vilhelmsson Timmermand, Ariana Huebner, Charles Swanton, Robert E. Hynds, Gina M. DeNicola, Timothy H. Witney
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54852-4
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https://doi.org/10.1038/s41467-024-54852-4

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