Profiling of driver mutations in lung adenocarcinoma patients identifies rare compound EGFR mutations sensitive to second-generation EGFR-TKIs

Profiling of driver mutations in lung adenocarcinoma patients identifies rare compound EGFR mutations sensitive to second-generation EGFR-TKIs

Abstract Background Lung adenocarcinoma (LUAD) is the most predominant histological subtype of lung cancer characterized by driver mutations detected in a substantial proportion of the cases. Tyrosine kinase inhibitors (TKIs) are standard care for the patients with these mutations. In this study, we...

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Main Authors: Jun Li, Cuiyun Zhang, Yuping Guan, Siyu Wang, Jiawen Zheng, Junnan Feng, Sile Han, Ruijuan Ma, Pengfei Ren, Shasha Li, Harry J. M. Groen, Klaas Kok, Anke van den Berg, Bing Wei, Jie Ma, Hongle Li, Yongjun Guo
Format: Article
Language:English
Published: Springer 2024-12-01
Series:Holistic Integrative Oncology
Subjects:
Lung adenocarcinoma
EGFR
TKI sensitivity
Rare mutations
Compound mutations
Online Access:https://doi.org/10.1007/s44178-024-00139-z
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https://doi.org/10.1007/s44178-024-00139-z

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