Integrating computational approaches to uncover β-lactamase-associated resistance in diarrheagenic Escherichia coli from pediatric patients

Integrating computational approaches to uncover β-lactamase-associated resistance in diarrheagenic Escherichia coli from pediatric patients

Abstract Multidrug-resistant diarrheagenic Escherichia coli (MDR-DEC) increasingly complicates treatment of pediatric infections, largely due to β-lactamase-mediated resistance. Despite their clinical relevance, the evolutionary diversity, functional mechanisms, and therapeutic targeting of β-lactam...

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Bibliographic Details
Main Authors: Taru Singh, Chandra Shekhar, Saurabh Singh, Shukla Das
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Multidrug resistance
Diarrheagenic Escherichia coli
Amoxicillin
Ceftriaxone
β-lactamases
Online Access:https://doi.org/10.1038/s41598-025-16122-1
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https://doi.org/10.1038/s41598-025-16122-1

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