Cytokine screening identifies TNF to potentially enhance immunogenicity of pediatric sarcomas

Cytokine screening identifies TNF to potentially enhance immunogenicity of pediatric sarcomas

IntroductionPediatric sarcomas, including osteosarcoma (OS), Ewing sarcoma (EwS) and rhabdomyosarcoma (RMS) carry low somatic mutational burden and low MHC-I expression, posing a challenge for T cell therapies. Our previous study showed that mediators of monocyte maturation sensitized the EwS cell l...

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Main Authors: Hendrik Gassmann, Melanie Thiede, Jennifer Weiß, Emilie Biele, Luisa Flohé, Helena Lachermaier, Carolin Prexler, Valentina Evdokimova, Laszlo Radvanyi, Irfan Akhtar, Mina N. F. Morcos, Franziska Auer, Sebastian J. Schober, Julia Hauer, Uwe Thiel, Kristina von Heyking
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
pediatric sarcomas
osteosarcoma
Ewing sarcoma
rhabdomyosarcoma
immunotherapy
adoptive T cell transfer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1347404/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1347404/full

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