Integrative spatial and genomic analysis of tumor heterogeneity with Tumoroscope

Integrative spatial and genomic analysis of tumor heterogeneity with Tumoroscope

Abstract Spatial and genomic heterogeneity of tumors are crucial factors influencing cancer progression, treatment, and survival. However, a technology for direct mapping the clones in the tumor tissue based on somatic point mutations is lacking. Here, we propose Tumoroscope, the first probabilistic...

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Main Authors: Shadi Shafighi, Agnieszka Geras, Barbara Jurzysta, Alireza Sahaf Naeini, Igor Filipiuk, Alicja Rączkowska, Hosein Toosi, Łukasz Koperski, Kim Thrane, Camilla Engblom, Jeff E. Mold, Xinsong Chen, Johan Hartman, Dominika Nowis, Alessandra Carbone, Jens Lagergren, Ewa Szczurek
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-53374-3
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https://doi.org/10.1038/s41467-024-53374-3

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